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Pregnant females were fed a vitamin D-deficient diet starting from day-16 gestation (last trimester) to focus on immune-mediated mechanisms of disease development in offspring and to limit any effects of in utero vitamin D deficiency on foetal lung growth and development (27).
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Any misclassification is likely to be non-differential with respect to development of asthma in offspring, and will bias the risk estimates toward the null.
Our objective was to determine the effect of maternal obesity on development of NAFPD in offspring and ascertain contributions of the intra/extra-uterine periods.
Consistent with this, the present study found more knee cartilage defect development in offspring in medial, patellar and total compartments.
Recent studies have also reported developmental toxicity from PFOA in rodents, including pregnancy loss, reduced fetal weight, reduced postnatal survival, and delays in postnatal growth and development in offspring (Butenhoff et al. 2004; Lau et al. 2004, 2006).
In conclusion, acute administration of the mixture of ATR and its metabolites during gestation had a significant effect on mammary growth and development in female offspring and these effects persisted into adulthood.
When this compound is elevated during gestation, it can stunt behavioral and intellectual development in offspring.
Exposures to PAHs during pregnancy have been linked to decreased birth weight and impaired development in offspring [ 14].
In areas where iodine intake is marginal (< 100 μg/day), low serum T4 and T3 levels (hypothyroidism), enlarged thyroid, and goiter were often detected in pregnant women, with impaired intellectual and physical development in offspring (Caron et al. 1997; Glinoer 2001).
This way, the present findings point to preventive action of dietary GEN on deleterious effects of gestational BPA exposure in both early and late prostate development in offspring F1.
Maternal BLLs of approximately 10 μg/dL have been linked to increased risks of pregnancy hypertension, spontaneous abortion, and reduced neurobehavioral development in offspring.
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