The differences in photoperiod and water temperature are certainly prime candidates to explain the slightly slower development in Experiment 1A.
The 3 groups were used to examine changes in gene expression between key stages in follicle development in 3 experiments; Experiment 1, gene expression in FR vs. AL broiler breeders was compared using microarray analysis of key stages of follicle development to determine the differences between birds with a low rate of follicle selection and birds with a high rate of follicle selection.
However, direct measurements of heteroplasmy were not made at each stage in development in these experiments.
Nonetheless, subcutaneous pre-immunization with BiP coupled with adjuvant induced no significant effects on CIA development in our experiments.
The upstream MXAN_4564 gene was found to be down-regulated during development in microarray experiments [ 58, 59].
However, DNA co-injections did not affect embryonic development in transient experiments when the HSP70 promoter was used to control Gal4/Vp16 expression (Fig. 1B,1B',1B,1B,1B,1B,1B,1B).
The sapA (MXAN_7407) and sapB (MXAN_3885) genes were reported to be down- and up-regulated, respectively, during development in microarray experiments [ 58, 59] (Additional file 7).
In order to characterize the effects of E2 on Th17 cell development in arthritis, experiments were terminated at different time points during the induction phase of CIA, and Th17 cells in LNs were studied.
Also worth noting are two putative MrpC binding sites in the vicinity of epsL (MXAN_7437, aka czc3A; Additional file 6), a gene noted above as down-regulated during development in microarray experiments [ 58, 59] (Additional file 7, column B).
Two new technologies are likely to revolutionize cardiac safety and drug development: in vitro experiments on human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and in silico human adult ventricular cardiomyocyte (hAdultV-CM) models.
