But anatomical features like simpler brains, kinked cilia, and a different pattern of development had suggested that acoels might not be related to other flatworms.
Historically, anatomical and developmental differences among eyes of different species favored homoplasy; however, recent molecular data indicating that all eyes employ a similar cascade of transcription factors (proteins regulating gene expression) for development have suggested homology.
Previous studies in endothelial cell migration during vascular development have suggested that BMP signals promote migration [28], whereas Notch activity inhibits migration [29].
For example, critical reviews of the Faroe Islands study of methylmercury and child development have suggested that the effects attributed to intrauterine exposure to methylmercury might be the consequence of co-exposures to high levels of PCBs [ Myers and Davidson 2000; Toxicology Excellence for Risk Assessment (TERA) 1999].
Subsequent developments have suggested various modes of attachment of the adsorbed and adsorbing species.
While there had been hopes of an economic recovery in those markets, recent data and developments have suggested that the recovery may take much longer.
Recent developments have suggested metabolomics is the relatively new field in bioinformatics that uses measurements on metabolite abundance as a tool for disease diagnosis and other medical purposes [ 17].
A clinical development model has suggested that cancer vaccines be investigated in 2 categories of clinical trials: proof-of- principle and efficacy.
Across a range of disorders within both typical and atypical development, research has suggested that individual differences in early AC/WM, along with the related domain of processing speed, correlate with subsequent learning abilities in a range of different domains.
However, the 'two-hit theory' 44 and multistep theory 45 of carcinogenesis suggest that at least two mutagenic hits are necessary for cancer development; research has suggested that some childhood cancers, including leukaemias 46 and CNS tumours, 47 are initiated in utero.
