Sentence examples for development from normal from inspiring English sources

The natural history of T2D describes the process of the development from normal glucose tolerance (NGT) via so-called pre-diabetic states, which are characterized by higher insulin resistance and/or reduced insulin secretion, to T2D.

Rip1-Tag2 mice display a reproducible pattern of multistage tumor development, from normal islets to hyperplastic/dysplastic islets, to angiogenic islets, to varying grades of solid tumor, with a well-defined angiogenic progression [ 27].

It is understandable that transitional molecular changes represented by gene sets may demonstrate mechanistic trend of development from normal tissue to cancer tissue, however, whether such changes can be prognostic may be another question.

We are currently aware of many of the molecular biomarkers that may be indicative of a development from normal breast epithelium to ADH, which will be discussed in detail below.

Thus, parasympathetic tone may decline with an autonomic imbalance shifting toward augmented sympathetic tone during the development from normal glucose tolerance to impaired glucose tolerance and finally diabetes [ 7].

Therefore, continued efforts to understand the linear view of breast cancer progression and, in particular, what causes this development from normal, to premalignant, to malignant stages will offer necessary information in efforts to develop new effective treatments.

Today a consensus is established as to how pathological development differs from normal development.

Neuromotor development ranged from normal to severe delay with epilepsy.

The human MCF10A system consists of a series MEC cell lines that share a common ancestry and represent distinct stages of breast cancer development, ranging from normal to highly invasive and metastatic [ 55]; they also represent a model system for studying the conversion of TGF-β from a tumor suppressor to a tumor promoter [ 9].

Selamat et al. have further mapped early, intermediate, and late methylation changes occurring throughout the development from histologically normal lung tissue (adjacent to the tumor) to atypical adenomatous hyperplasia, further to adenocarcinoma in situ and invasive lung adenocarcinoma.

Our previous, cross-sectional study indicated a preferential risk of HPV18 for the development of cancer from normal cytology (Bulk et al, 2006).