In order to develop an understanding of the roles of proteins in cellular dynamics, especially for the purposes of uncovering key players in disease development and for discovery of novel therapeutic targets, their physiological interactions must first be understood [ 1].
The further analysis and detailed results of these mutants as well as their impact on biophysical assay development for drug discovery can be found in "Method for Rapid Optimization of Recombinant GPCR Protein Expression and Stability using Virus-Like Particles" (Ho et al., 2017) [2].
Given the need for novel directions that can potentially diminish or resolve the onset and progression of neurological disorders, mammalian forkhead transcription factors are surfacing as potential effective targets that can offer new developments for drug discovery.
The data presented herein address the challenges of the first two steps of methylation biomarker development for clinical use: discovery and initial clinical validation.
Actinomycetes produce a large variety of pharmaceutically active compounds, yet production titers often require to be improved for discovery, development and large-scale manufacturing.
As the mechanisms for discovery, development, and delivery of new vaccines become increasingly complex, strategic planning and priority setting have become ever more crucial.
Additionally, the issues of low cost, low power and radio frequency (RF) GHz performance objectives has lead to both revolutionary as well as derivative technologies; these have opened new doors for discovery, development and research in the area of on-chip ESD protection and design.
Additionally, the issues of low cost, low power and radio frequency (RF) GHz performance objectives has lead to both revolutionary as well as derivative technologies; these have opened new doors for discovery, development and research in the area of latchup and ESD.
These kinetoplastid diseases, also classified as 'neglected diseases', are diseases of poverty that have received limited funding for discovery, development and delivery of new tools.
Guidance for discovery, development and clinical testing of new drugs, vaccines and diagnostics has been discussed at length in the recent scientific literature.
