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Zona-free embryos at 4-cell stage were treated in the mixed medium containing KSOM and CM and then immunostained at E4.5 to test the effect of the condition medium on early embryo development fate.
We can now state our main result about the relationship between the stemness of cell lineages making up a tissue and the future development (fate) of that tissue.
What we will be focusing on here is the relation between the stem cells lineages (their stemness) and the future development (fate) of the tissue.
This hypothesis is supported by our results where we elucidated the migration and development fate of wt PTEN-GFP+ mesodermal cells (derived from transplanted primitive streak tissues transfected with wt PTEN-GFP).
The expert-driven queries consisted of a set of 1 chemokine receptor and 6 cytokines with potential significant roles in EPCs development fate: CXCR4, CXCL2, CXCL5, CXCL12, CCL7, CCL2 and CCL23.
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During thymocyte development, cell fate is determined by signals originating from the alphabeta T-cell receptor.
Lüthje, K. et al. The development and fate of follicular helper T cells defined by an IL-21 reporter mouse.
Elucidating the mechanism of cell lineage differentiation is critical for our understanding of development and fate manipulation.
Inman, J. L., Robertson, C., Mott, J. D. & Bissell, M. J. Mammary gland development: cell fate specification, stem cells and the microenvironment.
Fuelled by plans of ski-slope development, the fate of Tromsdalstind caused a lively debate in local newspapers, as well as a report issued by the Sami Parliament.
Together, these data suggest that members of the NeuroD family are important for neuronal cell type identity and may be involved in several cell type-specific aspects of retinal development, including fate determination, differentiation, morphological development, and circuit formation.
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CEO of Professional Science Editing for Scientists @ prosciediting.com