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This is a BACE1 inhibitor that, as a development candidate, had been captured in GVKBIO CCD.
A roadmap for the selection of a pharmaceutical salt form for a development candidate is presented.
ASP8370 was selected as a clinical development candidate with significant ameliorative effects on neuropathic pain.
Several analogs were identified that maintained the antiviral activity of the previous development candidate against HCMV, HSV-1 and VZV, but with significantly improved aqueous solubility.
Among these compounds our development candidate, Gemifloxacin (Factive, LB20304a), showed the best in vivo efficacy and pharmacokinetic profile in animals, as well as good safety pharmacological properties.
UK-371,800 (compound 8) was identified as a development candidate from this series that married sildenafil-like molecular properties with high selectivity over PDE6.
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Combinatorial biosynthesis of polyketide synthases through genetic engineering should provide complex compounds as drug development candidates.
The results showed that compounds II were safe and eligible to be development candidates.
Strict application of these alerts to remove compounds from bioactivity screening libraries and lists of drug development candidates may significantly lower the productivity of new drug discovery.
As such, a rounded package of studies can be performed to help in the generation and selection of molecules as clinical development candidates.
We currently have two infectious disease vaccines in Phase 1 clinical studies and plan to progress several additional development candidates into the clinic by the end of 2016.
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