Exact(2)
Based on these initial experiments, we expected that other molecular factors involved in biofilm development and repression of biofilm could be found.
Through gene expression profiling, we show that HOXC9-induced neuronal differentiation is characterized at the molecular level by transcriptional regulation of 2,370 genes, with global activation of genes that promote nervous system development and repression of genes that are essential for cell cycle progression and the DNA damage response.
Similar(58)
Recent advances, particularly through genome analyses and cellular studies, increased our understanding of various local factors and cellular processes associated with the development, maintenance and repression of the corpus luteum.
Through these mechanisms, the SWI/SNF complexes have powerful effects on transcriptional regulation, serving an important role in development through the coordinate activation and repression of critical gene expression programs.
The activations of pluripotent factors and repression of development contribute to pluripotency in stem cells, while the activations of miRNAs further inhibit both DNA methylation and development.
This plasticity is tightly regulated during embryonic development and mediated by the exquisitely coordinated activation and repression of groups of genes.
This paper reveals a temporal uncoupling between CpG-island methylation and repression of transcription during early Xenopus laevis development.
As such, the mutual regulation between transcription factors and microRNAs regulate the bistable state between progenitor maintenance and myeloid development, where repression of inhibitory miRNA by histone demethylation of its promoter is associated with macrophage differentiation.
Thus, REST may play several roles during development, including repression of neuronal genes in the developing nervous system and later non-neuronal cells, and regulation of the terminal differentiation of neurons (reviewed by [ 74, 75]).
Recently, we demonstrated in a genetically engineered mouse model that BMI1 controls cellular interactions between granule and glial progenitors during cerebellar development through repression of the BMP pathway [ 17].
On the other hand tcf3, a gene encoding a helix-loop-helix transcription factor responsible for mesoderm and axis formation as well as anterior forebrain development via repression of wnt/beta-catenin targets, dramatically peaks at blastula and then exists as a stable polyadenylated transcript up to organogenesis (Additional file 1: Figure S5b) [ 41- 44].
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