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Use of the GLMM framework furthermore makes it easier for readers to follow the development and proof of the test statistic in Kasper (2017), and thus check the validity of our application of this test statistic in our current study.
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Although such firms typically concentrated their early efforts on technology development and proof-of-concept testing, they recognized the need for regulatory affairs expertise.
As a complement, we present novel experimental results on the development and proof-of-concept application of a combinatorial approach to study molecular recognition in CA and its inhibition by peptide compounds.
Presently, there are no clade B arenavirus infection models outside of newborn mice suitable for early stage antiviral drug development and proof-of-concept studies.
This was a reasonable strategy at an early stage of technique development and proof-of-principle studies.
Here we report the development and proof-of-principle application of an integrated SPE-nanoLC-MS chip for on-chip and online SPE-nanoflow LC-nanoESI-MS analysis of PFCs in small volumes of human blood samples.
Accordingly, in this phase 3 biomarker development and proof-of-concept study, we investigated whether urine YKL-40 on the day of AKI diagnosis from any cause can help predict outcome in hospitalized patients.
In these studies, we develop RNAi techniques for D. pulex by first determining the optimum culture conditions of their isolated embryos and then applying these conditions to the development of microinjection techniques and proof-of-principle RNAi experiments.
This provides a starting point, and proof of principle, for the development of further tools for the study of trypanosome differentiation and developmental gene regulation.
This work describes the proof-of-concept design, development and validation of a 3D multilayer microfluidic chip-based system for real-time developmental analysis of zebrafish embryos.
Transcriptomic analyses provide a promising means of furthering the field of environmental toxicology, with several applications having been realized in full and other applications, including biomarker development, having proof-of-concept models in place [ 14].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com