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This Review develops a theoretical framework for the development and onset of vulnerability in later life based on the concept of reserves.
Previous studies with NOD.IL4 and NOD.B10-H2(b).IL4 mice suggest that the Th2 cytokine, IL-4, plays a vital role in the development and onset of SjS-like disease in the NOD mouse model.
While studies of transcriptome profiles from larval invertebrates are limited, findings in polychaetes and ascidians suggest extensive variation in gene expression with development and onset of metamorphosis [60], [61].
A genetic predisposition for development and onset of SjS-like disease in NOD mice has also been defined.
In the present study, we investigated the function of IL-17A on the development and onset of SS.
UK service structure necessitates a transition out of youth services at a time of increased risk for the development and onset of mental disorders.
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Other studies have examined overall pubertal development without distinguishing between onset of breast development (thelarche) and onset of pubic hair (pubarche) development.
Prepubertal females would have similarly added fat in conjunction with the acceleration of development and earlier onset of sexual maturity.
There was a strong temporal conservation of expression during the time of rapid axon development and the onset of robust synapse formation.
We have previously used an animal model to explore the association between birth weight and the predisposition of macrosomic pups of diabetic dams to obesity development and the onset of adult diabetes as discussed by Merzouk et al. [ 3].
More generally still, it is now recognized that maternal health, independent of genetics, is a major contributor to child development and the onset of disease [1].
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