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Malaria parasite mainly causes disease while undergoing asexual development and multiplication within human erythrocytes.
This holding period provided time for the development and multiplication of A. marginale in tick midguts and other tissues [ 29].
Development and multiplication of A. marginale in salivary gland cells involves molecular interactions between pathogen- and tick-derived molecules.
The life cycle of schistosomes is complex, requiring specific freshwater snails as intermediate hosts for larvae development and multiplication.
Accordingly, the parasite produces and transports large amounts of lipid precursors and actively uses them to synthesize the membrane components needed during its rapid development and multiplication.
The subsequent development and multiplication of the breed, from a small founder population with a narrow genetic base and the long-term maintenance of the breed as a closed flock, are also possible contributing factors.
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Together, these genetic and inhibitor studies suggest that CDPK1 might be a good target for drug development to inhibit the parasite growth and multiplication that is responsible for the disease.
While it has a complex life cycle, it only causes disease while undergoing development and asexual multiplication within human erythrocytes where it alters its host cell to support nutrient uptake, reproduction, and immune evasion (Miller et al., 2002).
SmTK3 (Smp_054500) and SmTK5 (Smp_136300) - src family members, and SmTK4 (Smp_149460) - syk family, are present in reproductive organs and possibly involved in the development of gonads and multiplication of germinal and vitelline cells [ 82- 84].
Under the New Alliance for Food Security and Nutrition, Ethiopia is to change its seed law and policies to increase and incentivise private investment in the development, multiplication and distribution of seeds.
Stressful life, concentration of animals and the presence of different species in a small living space actuate development, multiplication and spreading of parasites, which in nature live in cohabitation with their hosts.
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