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Stimulation of these agonist pathways has been reported to lead to increased T-cell activation, proliferation, expansion, survival, memory formation, TH1 development, and induction of interleukin (IL -2 and IL -2immune responses27, 28.
The CCAAT/enhancer binding proteins (C/EBPs) are transcription factors involved in hematopoietic cell development and induction of several inflammatory mediators.
A possible contribution of TLR9 to early B-cell development and induction of central tolerance is also worth considering.
Commensal bacteria are critically required for proper gut-associated lymphoid tissue (GALT) development and induction of oral tolerance [ 3, 4].
The genes not induced by PoA include GO terms such as developmental process, cell differentiation, gamete generation, anatomical structure development, organelle organization and biogenesis, neuron development, and induction of programmed cell death.
A-FABP overproduction is believed to play a central role in obesity-related CV disease and endothelial dysfunction by increasing cholesterol and triglyceride accumulation, leading to foam cell development and induction of pro-inflammatory genes.
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Here, we identify a novel link between metabolic adaptation during development and induction and maintenance of autophagy, mediated by the tumor suppressor Lkb1.
Given the role of CD95L in the development of T cells and induction of AICD, mitochondrial damage could result in impaired thymocyte development and the inability to eliminate auto-reactive T cells.
The immunosuppressive effects of IL-27 depend on inhibition of the development of Th17 cells and induction of IL-10 production [ 53].
Quantitative analysis of coronary development and timed induction of AplnCreER fate tracing showed that the progenies of subepicardial endothelial cells (ECs) both invade the compact myocardium to form coronary arteries and remain on the surface to produce veins.
Previous studies have implicated changes in miRNA expression in the regulation of development and the induction of diseases such as cancer.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com