Maathai became the first East African woman to hold a doctorate (one section of Unbowed begins, divertingly: "In 1971, I completed my PhD on the development and differentiation of gonads in bovines").
In this section, we will discuss recent progress in understanding the role of the Notch pathway in development and differentiation of myeloid cells.
Interestingly, we found that the identified pathways have roles in development and differentiation of ES cells.
DNA methylation is essential for normal development and differentiation of plants and mammals [1] [11].
MafB is a TF with a role in the development and differentiation of several tissues [41].
The miRNAs play important roles in development and differentiation of human organs [9] [12].
Because KLF4 is vital in the development and differentiation of stem cells, KLF4−/− mice are embryonic lethal.
Hepatic stem cells co-express mesenchymal and epithelial markers; the mesenchymal−epithelial transition occurred in both liver development and differentiation of hepatic stem/progenitor cells in vitro.
Urogenital sinus mesenchyme induces, for instance, development and differentiation of epithelial cells that in turn control differentiation and localization of mesenchymal progenitors.
Together, these results demonstrate a crucial role for Creb1 activity for the development and differentiation of the conducting and distal lung epithelium.
In summary, it seems that stochastic fluctuations, whilst problematic in a homeostatic context, may prove to be essential within the context of development and differentiation of cellular populations.
