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It is possible that Runx genes are generally required for coordinating cell proliferation and differentiation during animal development, a requirement that would be masked by the idiosyncrasies of their mRNA expression patterns as well as by functional redundancies between paralogs in model systems that contain multiple Runx genes.
Under the draft guidance, companies may be required to submit microarray data used to determine differential dosing of a medication by genotype during development (a requirement that applies to animal testing as well as human clinical trials).
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Loss of one allele of COX-2 reduced tumor development by 50% while loss of both alleles completely prevented tumor development, demonstrating a requirement for the PGs generated from COX-2 in the development of skin tumors in the BK5.EP1 model [ 37].
"Engineers operate in many different industries, in government, in research and internationally," so "the need to retrain is constant — continuing professional development is a requirement of registration".
"For the first time, we've added professional development as a requirement in the Teacher Incentive Fund plan in the last round of dollars -- the $42 million allocated last fall".
GPs were allocated continuing professional development points (a requirement for continuing registration as a GP) for attending a training workshop and additional points for trial participation.
Depending on how universities respond, NIH may make career-development training a requirement in the future, experienced readers of institutional tea leaves believe.
Nearly all cell division mutants in Drosophila were recovered in late larval/pupal lethal screens, with less than 10 embryonic lethal mutants identified, because larval development occurs without a requirement for cell division.
6.2 Development Requirements Development requirements are minimal, since the site will only be a few pages.
Thus, the GAP activity of CYK-4 is not essential for post embryonic development but it has an important role in gonad development, likely due to a requirement for post-embryonic cell proliferation in the germline.
On March 10, Mr. Horton and two town board members presented three initiatives to address the townwide shortage of lower-income housing, including the establishment of an affordable housing fund, a transfer of development rights program and a requirement that 25percentt of all new subdivisions be allocated for lower-income housing.
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