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The effects of L-NAME suggest that parasites are targeted before or during the oocyst development, a hypothesis which seems to be consistent with the demonstrated susceptibility of parasites to NO damage [56].
Such a scenario could be biologically plausible if lipid levels during childhood affect brain development, a hypothesis that has been put forward with regard to the ε4 allele and cholesterol levels and for which there is some evidence in the literature (28,29).
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These studies, together with our evidence of higher population differentiation in the genes involved in the hair follicle development support a hypothesis of adaptive evolution accounting for the diversification of human hair.
The overall development of a hypothesis for such interactions relies on knowledge of the plant variety and previous characterizations of the parental GM (single).
As is the case for all exploratory retrospective studies, the most important outcome that can be achieved is the development of a hypothesis suggested by the results.
There is a demonstrable association of cholera outbreaks with El Niño conditions [ 6], leading to the development of a hypothesis that climate-driven events enhance the emergence of virulent strains of Vibrio cholera with transmission to humans through marine invertebrates.
This, in turn, would require the development of a hypothesis-driven card stimulus set that would be the basis of the card sorting task.
The purposeful development of a hypothesis-driven card set was nontrivial, requiring each card to be able to be seen in the context of both of these two hypothesized conceptual frameworks, as well as to be in language that was as accessible as possible to both novices and experts.
Furthermore, in addition to inflammation being considered nonessential for the development of IPF/UIP, a hypothesis was proposed that inflammation may actually be beneficial in this disease process [ 5].
We consider two hypotheses for explaining and perhaps reducing shallow strategy development: a student-centered hypothesis related to "gaming the system," and a design-centered hypothesis regarding how students are scaffolded via the system.
173 The BCAA overload hypothesis suggests that in the context of a dietary pattern that includes high fat consumption, BCAAs may make an independent contribution to the development of insulin resistance, a hypothesis supported by metabolomic studies demonstrating high BCAA levels in normoglycemic individuals that subsequently develop insulin resistance and diabetes.
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