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Since thyroid hormones are essential for fetal and early life neurologic development, a disruption by prenatal PFAS exposures could possibly impair healthy neurodevelopment.
As constitutive Ras activation is incompatible with prenatal development, a disruption of mitochondrial energy metabolism could underlie tumor formation in mice cloned from melanoma nuclei following the inadvertent expression of the Ras oncogene (48).
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DNA methylation is thought to be the main epigenetic mechanism operating during placental development; any disruption in placental methylation pattern leads to aberrant function of the placenta [ 21].
The fundamental importance of TOR is underscored by genetic studies showing TOR to be essential for cell growth and development; disruption of the TOR gene is lethal in all examined species [4] [12].
Mr. Bush needs to see these developments as an opportunity, not a disruption.
One such alternate mechanism for the production of LDGs would be a disruption in granulocyte development.
If there is a disruption in the development for example, through serious trauma that is not addressed early on, it could result in life-long development problems.
However, despite effective treatment of the vascular injury, many children suffer vision impairment, suggesting a disruption of neuronal development as well.
Childhood epilepsy, schizophrenia, and autism have all been linked to a disruption in the development of populations of interneurons (Ben-Ari et al. 2004; Levitt et al. 2004).
This is because Plasmodium is haploid during ABS development; therefore disruption of a gene essential for ABS would result in parasites that can not be selected after transfection as the deletion is lethal.
Three possible explanations are: (i) haploinsufficiency for another locus (or loci) in the T hp deletion, exacerbating the disruption to XY gonad development; (ii) disruption to a testis-determining gene outside, but close to, the T hp deletion in the form of a position effect or (iii) the presence of the deletion itself contributing to disruption to testis determination.
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