Given the increasing prevalence of NAFLD, it is essential that we further understand the genetics and pathophysiology of fatty liver diseases so that we can develop rationale therapeutic options for this common liver disease.
The second 'experiment' has been the use of large-scale biological models such as cancer cell lines to correlate mutations in cancer genes with drug sensitivity, such that one could begin to develop rationale clinical trials to begin to test these hypotheses.
Yet the field of gerontology has assumed that some type(s) of inexorable damage or cumulative disruption is the entire source of aging, from its inception with Aristotle to the free-radical theory of aging to the recently developed rationale for SENS [ 3, 16].
In concrete terms, this faith in the healthful qualities of breast milk was sometimes expressed as a vague sense that "breast milk is best," though sometimes women had more developed rationales: A number of women suggested that breast milk is more easily digested, and nutrients more easily absorbed than formula.
Some theorists have sought to develop rationales consistent with political liberalism, arguing, for instance, that the intimate dyadic marital relationship protects autonomy (Bennett 2003), or that marriage could be justified by its role in protecting caring relationships (Brake 2012), caregivers and children (Hartley and Watson 2012).
ON encouraged health units to develop rationales, local evidence reviews and local health standards to support health improvements.
However, the understanding of the biological mechanisms by which these agents may cooperate in cancer patients may help to develop rationale-based combinations and maximise therapeutic effects.
The most outspoken among them had leading roles in developing the rationale and, in some cases, the plan for invading Iraq and deposing Saddam Hussein.
These kinds of results, Young has written, "should be viewed with some skepticism, since the human imagination seems capable of developing a rationale from most findings, however unanticipated".
"The Bush administration appears to be slowly but steadily moving in the direction of removing the obstacles preventing a resumption of U.S. testing and developing a rationale for resuming testing," said Daryl G. Kimball, executive director of the Arms Control Association.
