In particular, developing predictors based on multiple SH2 domain probes is likely to improve the discriminating power of SH2 profiling, and is therefore a high priority for future studies.
Other possible aims with pre-specified groups include demonstrating global differences between groups using multivariate analysis (without identifying individual genes that are differentially expressed), and developing predictors of group membership (Golub et al, 1999; Hedenfalk et al, 2001).
Another advantage of the split sample method, particularly in large collaborative studies in which multiple groups will be developing predictors, is that the test set can be kept under "lock and key" by a honest broker [ 4].
In conclusion our work highlights the usefulness of developing predictors starting from species-specific data, so as to capture features which are characteristic of a given organism, or, such as in this case, group of organisms.
Cox regression models (univariable and multivariable) were used to develop predictor models using all baseline variables.
A second neoadjuvant study was recently published using cDNA arrays to develop predictor for paclitaxel, fluorouracil, doxorubicin, and cyclophosphamide, involving 24 samples.
The purpose of this five-year project was to develop predictors of lawyering effectiveness that could be used in law school admissions decisions.
To develop predictors of outcome, 22 admission characteristics of 221 consecutive discharges in two nursing homes were analyzed using automatic interaction detector analysis.
A second neoadjuvant study was recently published with the use of cDNA arrays to develop predictors for paclitaxel, fluorouracil, doxorubicin, and cyclophosphamide, involving 24 samples.
