Discovering the critical molecular mechanisms of TNBC and developing new compounds targeting these mechanisms may advance the development of TNBC treatments.
This gives pioneers time to recoup the costs of researching and developing new compounds, vital when creating a new medicine can cost up to $5 billion.
For this reason, pharma industries are increasingly using drug repositioning in order to find alternative applications for their drugs, reducing time and costs involved in the process of developing new compounds [ 14, 15].
Adverse effects of glucocorticoids could be limited by developing new compounds that selectively modulate anti-inflammatory activity of the glucocorticoid receptor (GR).
The reason, Dame Sally says, is market failure – for Big Pharma, there is little money in expensively developing new compounds which will only be taken in short courses, compared to a drug for blood pressure, say, which may have lifelong use for patients.
Developing new compounds for addressing cognitive impairment in schizophrenia is a challenge given the complexity of the human brain and the limited translationability of preclinical animal models.
Consequently, scientific efforts have been made to study and develop new compounds to be used beyond conventional antibiotic and antifungal therapy.
In order to develop new compounds with antioxidant effects and potential applications in antidiabetic therapy, new thiazolidine-4-one derivatives with xanthine structure have been synthesized.
Anacor, which last year won a $21.6 million grant from the U.S. Department of Defense to develop new compounds, has already started animal tests and expects to have drugs in human trials within three years.
Researchers also are exploiting the new genomic information to create genetically altered mosquitoes that resist parasite infection and to develop new compounds that overcome or avoid resistance to existing pesticides (17 ).
