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Serum levels of adiponectin are reduced in obese individuals, and inversely correlate with several diseases, including type II diabetes [1], cardiovascular diseases [2] and metabolic syndromes [3], as well as the risk of developing multiple types of cancers [4].
As noted above, epidemiological evidence shows that individuals with diabetes have significantly higher likelihood of developing multiple types of cancers [ 3].
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In recent years, the NIH has developed multiple types of funding beyond the traditional R01 grants.
HMPS is a rare, autosomal-dominant condition in which patients develop multiple types of colorectal polyp and cancer.
More importantly, both Fbx4 +/− and Fbx4 −/− mice develop multiple types of tumors, including lymphomas, histiocytic sarcomas and, less frequently, mammary and hepatocellular carcinomas.
In support of this notion, in vivo knock-in mice harboring tumor-derived mutants of p53 tend to develop multiple types of tumors as well as more metastatic and invasive tumors compared with p53 null mice.
Furthermore, the −652 6N ins/del promoter variant (rs3834129) has been associated with the risk of developing multiple tumour types, including CRC in the Chinese population (Sun et al, 2007).
As a result, a DAYCENT model-GIS platform was developed that integrates multiple types of pedo-climatic and land management information.
To summarize, a robotic micromanipulation system was developed to position multiple types of single cells on a variety of substrates.
The remaining 30% of the patients eventually develop resistance to multiple types of chemotherapy.
Several methods have been developed to integrate multiple types of data to infer a transcription regulatory network in eQTL analysis, including mRNA expression, chip-chip, physical interaction and protein phosphorylation [ 5- 8].
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