If high dosages are being employed during the initial trial and during the initial period of therapy, many patients will develop intolerance and side effects and eventually shy away from the further use of indomethacin.
"After 9/11, people got frightened and began to develop intolerance for Muslims as a group, which I think is so unfair," Dendinger said.
The contact lens acceptance was very high and only one patient developed intolerance to it.
A total of 11 patients (18%) developed intolerance to either the ventilation or the interface during NIV treatment.
Interestingly, these mice had impaired oral glucose tolerance from week 12, and later, at week 20, also developed intolerance to intravenous glucose loads.
Sunitinib has improved clinical outcomes for patients with progressive unresectable gastrointestinal stromal tumors (GIST) or who develop intolerance to imatinib mesylate and it is reasonably well tolerated [ 1- 5].
Instead, Hamilton et al. [ 14] suggested that Cenozoic changes in sea level essentially stranded the ancestors of extant river dolphins in different river systems, where they subsequently developed intolerance to salt water on at least three occasions.
Overall, imatinib, dasatinib, and nilotinib are associated with manageable side effect profiles in most patients with CML; however, some patients have been found to develop intolerance to each of these TKIs 12– 12.
A relevant percentage of patients with metastatic renal cell carcinoma develop intolerance to vascular endothelial growth factor receptor-tyrosine kinase inhibitors (VEGFr-TKIs) and require careful selection of subsequent treatment.
With advancing age, the risk of developing exercise intolerance, atrial fibrillation or even decompensated right heart failure and pulmonary hypertension increases [11].
We conclude that routine CPET may be a sensitive method to detect developing exercise intolerance and provide additional information on the mechanism of exercise limitation in SSc.
