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Carriers of the mutant allele showed a lower risk of developing grades 3 4 toxicity.
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Grade 3/4 hematologic toxicities were minimal, with only two patients (5%) developing Grade 3 thrombocytopenia.
9 of 12 patients developed acute GVHD, with 4 developing Grade III IV GVHD.
Treatment was well tolerated, with only one patient developing grade 3 RTOG skin toxicity.
The odds ratio for inoperable patients developing grade ≥ 3 toxicity was 2.68 (confidence interval 1.01-6.77.5).
Minimal alopecia was seen, with one patient developing grade 1 hair loss.
Eighteen patients (42%) developed grades II to IV acute GVHD and five (12%) developed grades III to IV acute GVHD.
Most of the patients developed grades 1 2 acute toxicities.
Four patients developed Grade ≥ 2 chronic toxicity.
Results: Forty-four patients developed grade 2/3 oxaliplatin-induced neuropathy.
Eleven percent developed grade 3 hallucinations.
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