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He has previously shown that biallelic loss of Nf2 is rate-limiting for meningioma development with mice developing grade I meningiomas.
Treatment was well tolerated, with only one patient developing grade 3 RTOG skin toxicity.
The odds ratio for inoperable patients developing grade ≥ 3 toxicity was 2.68 (confidence interval 1.01-6.77.5).
Minimal alopecia was seen, with one patient developing grade 1 hair loss.
Grade 3/4 hematologic toxicities were minimal, with only two patients (5%) developing Grade 3 thrombocytopenia.
Haematological toxicity was considerable, with all patients developing grade 4 myelosuppression.
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Twenty-two percent developed grade 3 fatigue.
Eleven percent developed grade 3 hallucinations.
Results: Forty-four patients developed grade 2/3 oxaliplatin-induced neuropathy.
According to the NCI Common Terminology Criteria v3, five patients developed grade 1 to 2 thrombocytopenia and two patients developed grade 3 to 4 thrombocytopenia, and three patients developed grade 1 to 2 leucopenia.
One developed Grade 2 hyperbilirubinemia.
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