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Adapting this guidance to suit local circumstances and resources as well as developing (for each potential patient) a checklist, placed in the notes to aid planning, preparation, implementation and debrief, is recommended.
Kinetics of channel block have been ignored (voltage-/state-dependence, and allosteric effects); however, it would be difficult to include these effects: early safety testing does not measure such intricate details of compound channel interactions as standard, and each compound would need associated channel block models developing for each ion channel.
Similar(58)
Steady-state computer models are developed for each electrode system.
Models are developed for each of these conditions.
Separate LUR models were developed for each network.
Reconfiguration concepts are then developed for each identified RBPT module.
Ratios are developed for each method based on real data.
The empirical models were developed for each factorial analysis.
An indirect cost rate should be developed for each separate indirect cost pool developed.
In Maryland, for example, half an acre is developed for each new resident.
Efficient heuristics are developed for each step of the design flow.
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