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However, immunocompromised patients, and particularly allogeneic hematopoietic stem cell transplant recipients, are at high risk of developing disseminated and potentially fatal disease.
Similarly, many patients at low risk of developing disseminated disease undergo toxic adjuvant chemotherapy treatments that are of little benefit.
62 Similarly, a study of Kern County, California coccidioidomycosis cases found that older age was independently associated with developing severe pulmonary disease, but not with developing disseminated disease.
Based on the evidence that children who were HIV-infected when vaccinated with BCG at birth were at increased risk of developing disseminated BCG disease, WHO, in 2007, recommended that HIV-infected children should not be vaccinated with BCG [ 17].
Prothrombin complex concentrate contains vitamin K-dependent coagulation factors II, VII, IX, and X, normalizes the INR more rapidly than FFP, and can be given in smaller volumes, but carries a higher risk for developing disseminated intra-vascular coagulation [ 76]. *See Table 1 for descriptions of Levels of Evidence.
Neither the time to metastatic disease nor the fraction of animals developing disseminated disease was affected by cyclosporin A. This observation indicates that T cells might be involved in the response process of RIT in our model.
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Genetic defects in IFN- γ signaling are rare disorders associated with high risk of developing disseminating NTM infection [ 16].
The CoP as a social interaction process was successful in achieving its primary objective related to KT: developing, disseminating, and archiving its webinar series.
Developing, disseminating and implementing appropriate policies and guidelines for all levels and sectors of maternal-newborn services were the major perceived governance bottlenecks for countries.
19 Across the analyses reporting costs, the estimated cost per patient of developing, disseminating, and implementing patient decision support interventions ranged from $2 to $400 per patient.
However, a smaller proportion of Ae. albopictus develops disseminated infection when compared to Ae. aegypti, suggesting that DENV dissemination by Ae. albopictus is less efficient [ 93].
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CEO of Professional Science Editing for Scientists @ prosciediting.com