Many patients with dementia develop agitation or aggression in the course of their disease.
On 47 occasions, patients developed agitation and were not awake; on 25 occasions, patients developed vital sign changes (in 8 out of 33 patients who were enrolled in the modified protocol).
We report a homozygous MAPT R406W mutation carrier who developed agitation, personality change and increased rigidity during his early thirties, followed by memory impairment, delusions, obsessive rituals and social disinhibition, leading to a diagnosis of bvFTD.
7 In this report, we provide a detailed description of a man homozygous for the R406W mutation who developed agitation and rigid personality during his early thirties, and memory impairment the following year.
Memantine has been shown to have a beneficial effect on the NPS of dementia in clinical trials 15 16 and a Cochrane Review meta-analysis showed that AD patients taking memantine were slightly less likely to develop agitation, although the review concluded that there was no evidence either way about whether memantine has an effect on agitation which is already present.
The patient in the case scenario developed agitation, which could have been a result of a variety of etiologies, including dyspnea, anxiety, pain (from the endotracheal tube, lying in bed, or from procedures), delirium induced by critical illness, alcohol withdrawal, or delirium tremens (de Wit et al. 2007 b ).
When patients developed sustained agitation, marked dyspnea, pulse oxymetry <88% for ≥5 minutes or arrhythmias, sedatives were restarted at one-half of the previous dose and then titrated to achieve the target sedation level.
A 3-year-old, 3.7 kg intact female Miniature Poodle who had been intentionally fed an unknown amount of a crystalline-like substance developed extreme agitation, seizures, tachycardia, hyperthermia, hypertension, disseminated intravascular coagulation (DIC), bloody diarrhea, and dilated pupils.
The objective of this work was to develop an agitation-based protocol for detachment of culturable bacterial communities from the biofilm surrounding pea gravel from constructed wetland mesocosms.
In patients in whom agitation developed, the median number of days with agitation events was greater for smokers than for nonsmokers.
