Existing efforts on developing a learning progression of scientific explanation need to be continued and extended in order to expand and deepen our understanding of how to help students develop competence in constructing scientific explanations.
Developing a learning progression involves centering instruction and assessment around a small number of major foundational concepts of a particular principle (e.g., diversity, variation, change, geologic processes in evolution) and these concepts serve as a collective "pathway" for learning throughout schooling (Catley et al. 2005).
With our overall goals of engaging students in deep learning of HPI concepts and developing a learning progression between our courses, the HPI-CI process was informing us in ways we had not expected.
The approach of developing a generic disease progression submodel and calibrating its parameters based on outcomes data was taken because of the lack of biological data needed to directly estimate these parameters.
It provides a simple foundation and gives room to develop a deeper progression as each layer is introduced.
A similar approach has also been taken by de Winter et al., who developed a disease progression model to investigate the long-term effects of pioglitazone, metformin, and gliclazide.
This study has identified eight proteins (CEA, IL-8, prolactin, amphiregulin, PDGF-BB, IL-6, CXCL11 and CXCL5) whose expression trends are of great interest for developing a "biosignatures" of CRC progression that could potentially be translated into a diagnostic/prognostic.
Developing a hypothetical multi-dimensional learning progression for the nature of matter.
Nonetheless, given the limited progression on developing a universally useful vaccine active against all pathogenic serovars, the most cost effective measure for a developing country is to work on a locally effective killed whole cell vaccine.
While this numeric gaze seems to develop on both sides of the risk divide, with those 'at risk' of cancer and those 'at risk' of cancer recurrence or progression each developing a sense of measured vulnerability, I have suggested that there are some potentially important differences in the meaning of these technologies for those living with realised risk.
