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Although several initially promising agents have been developed to reverse or at least slow the decline of cognitive function, successive experimental trials have failed.
UHRAs have been developed to reverse heparin effects but also displayed anticoagulant effects.
Through genome research, strategies are being developed to reverse its population decline.
HDAC inhibitors have been developed to reverse gene silencing by inhibiting HDAC activity and increasing histone acetylation.
Till now, no substantial therapeutic interventions have been developed to reverse established fibrosis or even halt the chronic progression to respiratory failure.
Resveratrol, a diet-derived polyphenol, is a prototype of a new class of drugs referred to as CR mimetics, which are being developed to reverse organ pathologies associated with aging and metabolic diseases [ 134].
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Several methods have been developed to reverse-engineer a cellular system, called a gene regulatory network, from gene expression profiles in order to understand transcriptomic behavior under various conditions of interest.
Attempts have been made to improve clinical outcomes for frail older people, however no interventions have been developed to specifically reverse the syndrome of frailty.
Previous studies have shown that clinical outcomes for frail older people can be improved using multi-factorial interventions such as comprehensive geriatric assessment, and single interventions such as exercise programs or nutritional supplementation, but no interventions have been developed to specifically reverse the syndrome of frailty.
From the standpoint of technological protection, several techniques have been developed to avoid reverse engineering, tampering, and illegal distribution of software.
This paper presents the results of analyses of a Discrete Element Methodology (DEM) developed to study reverse faulting through sandy layers, considering the inherent ability of DEM to model strain localization phenomena in granular soils; the paper emphasizes on engineering significances of the results.
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