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The cancer developed to block the ureteral tubes and also spread to regional lymph nodes.
But drugs might be developed to block insulin receptor sites the way tamoxifen blocks receptor sites for the hormone estrogen.
The compound is being developed to block a type of enzyme that allows cancer cells to divide and spread and normal cells to be turned into cancer cells, a Vertex spokesman, Michael Partridge, said.
Therapeutics are being developed to block TGF-β signaling.
For moderate-to-severe psoriasis, effective biologic therapies have been developed to block specific cytokines (e.g., etanercept) or interfere with T-cell activation (e.g., efalizumab).
Several chemicals, such as Nutlin and MI-219, have been developed to block the interaction between Mdm2 and p53 (Shangary et al., 2008; Vassilev et al., 2004).
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To avoid the side effects of GSIs, antibodies have been developed to specifically block the Notch1 receptor [ 33].
The EGF pathway contributes to the malignant potential of NSCLC and several compounds have been developed to selectively block this pathway, for example, the EGFR-TKIs gefitinib and erlotinib and the monoclonal antibody cetuximab.
The immune response developed to MSP1 block 2 has been associated with protection by some groups [ 57, 58], but not by others [ 34, 59, 60].
Since Mcm-2-7 levels appears to be critically balanced to prevent genome instability, drugs that modulate Mcm2-7 gexpressionsion could be profitably developed to either block cellular proliferation or potentially return it to normal levels.
The human innate immune system has developed to recognise and block biofilm development through the action of lactoferrin, at sub-bacteriocidal concentrations [ 75].
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