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Its signalling functions do include ligand binding, and although antibody therapeutics can be developed to bind its extracellular domain and interfere with ligand binding, it is not clear whether the oncogenic functions of activated EGFR or HER2 are driven by extracellular ligands.
But it is the proteins that actually carry out bodily functions, and drugs are developed to bind to particular proteins.
The C.I.A.'s printer, by contrast, was originally developed to bind together plastic polymers, which means that its users have exquisite control over how their food is assembled.
Many of them have been developed to bind to folded proteins, yet cellular networks for signaling and protein trafficking often depend on binding to unfolded regions of proteins.
Recently, a technology was developed to bind growth factors to a fibrin matrix using the transglutaminase (TG) activity of factor XIIIa, thus allowing prolonged release through enzymatic cleavage.
It is true that many "atypical" antipsychotics have been developed to bind several sites within the brain.
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An initial conceptual framework was developed to bound and guide the study.
These inhibitors have been developed to covalently bind to cysteines at specific sites of the kinase.
In the control system of the WNN sliding-mode, a WNN bound observer is developed to adjust the bound of uncertainties in real time.
In contrast to the conventional liposomes, positively charged cationic liposomes have been developed to be preferentially bound to, and internalized by angiogenic and negatively charged, endothelial cells that are found in tumours and in areas of chronic inflammation [ 54].
To overcome these limitations, ligand homology modeling (LHM) was developed to predict ligands that bind to the protein target [9 11].
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CEO of Professional Science Editing for Scientists @ prosciediting.com