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In our study, in order to suppress the progression of lung cancer metastasis in mice, we developed sticky siRNA (ssiRNA) to inhibit survivin and cyclin B1, two candidates involved in cell survival and proliferation.
To this end, we have developed sticky siRNAs (ssiRNAs) that mimic gene structure through reversible concatemerization brought by sticky 3'-complementary overhangs [ 32].
We used our newly developed sticky siRNA-based technology delivered with linear polyethyleneimine (PEI) to inhibit the expression of survivin and cyclin B1 both in vitro and in vivo, and addressed the effect of this inhibition on B16-F10 melanomaelanoma tumor development.
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No one will want to go near them (or develop sticky fingers) when checking your luggage!
Based on these researches and works, we developed a sticky-note-based interactive system by combining the input from digital pen and the output with motion which is made by SMA.
Early in his career, searching for a method of killing the fly without heavy spraying of pesticides, he helped to develop the sticky sphere trap.
Fully developing these sticky oil deposits will require clear-cutting or degrading largely intact primary boreal forests covering an area the size of England.
The effect was dramatic in mice bred to develop the sticky brain plaques and tangles that are a hallmark of Alzheimer's disease in humans.
At our agency this comes to life through an ongoing practice we developed called "The Sticky Religion" -- a vision board placed within the office where team members can contribute "intention" sticky notes, which can be added to and revisited frequently.
So refined is the aesthetic that at Yoga Shanti, I overheard one yoga princess complaining to her neighbor about a pea-size bubble that had developed in her sticky mat.
3. Add the wine and water to the meat mixture and mix in a stand mixer using a paddle attachment, or by hand with a sturdy spoon, until the liquids are incorporated and the mixture has developed a uniform, sticky appearance, about 1 minute on medium speed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com