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A recently developed selective u-PA inhibitor, WX-UK1 impaired development of lung metastases in a rat model of spontaneous metastatic orthotopic breast adenocarcinoma, whereas Ertongur et al (2004) demonstrated that this compound inhibited in vitro tumour cell Matrigel invasion by a variety of human cancer cell lines (Setyono-Han et al, 2005).
In summary, we have developed selective semi-synthesis of 5,8-dimethoxyl-6- 1-hydroxyl-4-methylpentyl -1,4-naphthaquinones (13) from natural product shikonin.
We developed selective and efficient syntheses to generate a series of mono 3/5/7/3′/4′-substituted flavonoid derivatives.
Udenafil is a newly developed selective phosphodiesterase type 5 inhibitor for the treatment of men with erectile dysfunction (ED).
As a consequence, he developed selective fluorogenic and chromogenic substrates and specific inhibitors of proteases that allow the (histochemical) analysis of protease activity.
The recently developed selective 5-HT4 receptor agonists such as prucalopride target 5-HT4 receptons on myenteric cholinergic neurons to enhance acetylcholine release and GI motility.
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The concepts of selectivity and additivity fields have been employed in developing selective CoMFA models for these related kinases.
Our results reveal the mechanism of selectivity and activation for H4R, which is important for developing selective antagonists and agonists for H4R.
He said he dealt with fame by developing "selective insensitivities".
But Lee Miles, Professor of Crisis and Disaster Management at Bournemouth University, says whatever crisis may befall an entrepreneur: "It's about finding a balance between a client expectation of 24/7 service delivery and developing selective resilience to keep the company operating.
It may therefore be necessary to develop selective FXR modulators.
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