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To study the role of host cellular factors in the mechanisms of resistance, we have developed resistant stable HCV replicon cells lines for HCV 1b and HCV 2a viruses by prolonged treatment with interferon alpha [21] [22].
In our current study, we developed resistant sublines and investigated the mechanisms of acquired resistance to treatment with the anti-EGFR mAb ICR62 and the EGFR TKI gefitinib in DiFi colorectal cancer cells.
You can't wipe it out with a single shot because by the time you've dealt with the last strain, a new one has developed resistant to previous remedies.
However, all sulfa drugs induced some of the side effects listed above, and bacteria developed resistant strains after exposure to the drugs.
All 30 patients were either paclitaxel and/or platinum resistant initially or developed resistant disease.
Nobel Peace Prize winner Norman Borlaug developed resistant varieties of wheat that protected the world against stem rust for decades.
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Therefore, utilization of BPH resistance genes in developing resistant varieties is considered as the most economical and eco-friendly approach to control this pest (Tanaka et al. 2000).
For developing resistant cultivars, wheat germplasm with effective resistance and genes conferring the resistance should be identified.
Identifying sources of resistance in Passiflora collections is the first step to develop resistant varieties.
In many ways, Ms. Dixon is typical of a patient who develops resistant hypertension.
Darwin was very concerned about the blight, Dr. Ristaino said, and gave Irish potato breeders £100 of his own money to support efforts to develop resistant strains.
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