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Then as the game developed Frank was able to go forward more and he played well.
A small fraction of the animals developed frank diabetes making it difficult to maintain the line.
In one study, 22% of patients treated with IFNα developed a positive blood test for ANA and 19% developed frank autoimmunity with one patient meeting the criteria for SLE diagnosis [24].
As addressed in the main text, these mechanisms remain poorly understood, although multiple within-host models for sequential waves of parasitaemia have been developed (Frank, 1999; Recker et al., 2004; Frank and Barbour, 2006).
Some 35 patients developed non-respiratory AOF, while 22 out of 60 patients (36.7%) with respiratory SOFA scores < 3 developed frank respiratory failure.
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These people face a very high risk of developing frank hypertension and its complications as they grow older, unless they do something now to lower their risk.
Patients with metabolic syndrome have a high risk of developing frank diabetes (3).
The development of diabetes in patients with liver cirrhosis occurs relatively rapidly; over a period of 5 years, ∼15 20% of cirrhotic patients develop frank hyperglycemia (39).
Furthermore, a subset of women develop frank thrombocytopaenia, often in association with haemolysis, elevated liver enzymes and low platelet count (HELLP) syndrome.
In the majority of cases, patients with mixed cryoglobulinemia present with intermittent nonspecific polyarthralgias involving the hands and knees whereas less than 10% develop frank nonerosive arthritis.
Second, the frequent occurrence at a young age of cognitive and motor abnormalities in those who subsequently develop frank illness was noted.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com