Subsequent to retrospective validation, multimarker models are developed, either as part of phase Ic, with the initial cohort of patients, or as part of phase II, in a retrospective study using patients different from those of phase I. Whether initially developed in phase I or II, this model will always undergo refinement with the second group of patients.
Hepatocellular carcinomas may develop either as a macroscopic nodule larger than 1 cm in maximum dimension or as multiple microscopic foci.
RCC etiology is yet unidentified, developing either as a sporadic form or as a hereditary disease, and whatever the subtype is, it is described as highly resistant to conventional radio-, chemo- and immunotherapy regimens [12], [15], [20].
Similar to mammals, most of the teleosts are gonochorists; individuals develop either as males or females and remain the same sex throughout their lives [ 1].
Heart failure due to iron overload can develop either as a result from repeated blood transfusions seen in thalassemias or hereditary hemochromatosis.
It occurs rarely in immunocompromised patients, especially in renal transplant recipients, but when it occurs it carries a very high incidence of morbidity and mortality [ 1], developing either as a reactivation of the virus in the form of zoster or as a primary varicella or chickenpox infection.
She added that she hoped that within two years, plans for artists' housing, developed either locally with Artspace as a consultant or by Artspace itself, would be under way.
One the other hand, the PTC certainly wasn't the audience Murphy had in mind when he developed either show: Both really are as explicit and gory as TV shows come these days. .
Currently, several pharmacological and genetic zebrafish models of epilepsy or behavioral seizures have been developed either by chemical induction (such as pentylenetetrazole and kainate) or genetic alteration (for a comprehensive review see Stewart et al., 2012).
The membranes were then incubated with the secondary antibody for 4 hours at RT, washed as before and developed either with ECL or Chemidox, (Biorad, Hercules, CA, USA) according to the manufacturer instructions.
Photochemical-driven motors have been developed either in a pump configuration or as self-propelled particles.
