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Since the discovery of differences in extent of excretion of isoniazid, a vast literature has developed documenting many other genetic polymorphisms for drug metabolizing enzymes and drug transporters.
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For more complex systems, more comprehensive procedures may need to be developed, documented and utilized.
(i Procedures shall be developed, documented and utilized for the control of potentially hazardous energy when employees are engaged in the activities covered by this section.
A full plan of study which will provide a record of sampling, analytical, and data reduction procedures must be developed, documented and approved by the EPA management authority.
In these cases, a narrative cost allocation methodology should be developed, documented, maintained for audit, or submitted, as appropriate, to the cognizant agency for indirect costs for review, negotiation, and approval.
Only six participants developed documented heart disease.
None developed documented bacterial or fungal infections.
Five patients (11%) developed documented infection, one of whom required hospitalisation for intravenous antibiotics.
Based on the results of this study, CTD staff designed, developed, documented and implemented a highly effective, fully functional text-mining pipeline (12).
Fifteen of these newborns developed documented intraventricular hemorrhage, leading to an estimate of 9%95(95 % CI: 5.3-15.0 %) of intraventricular and/or intraparenchymal hemorrhage in this population of newborns.
Of these five patients, three received AC/FAC, one received capecitabine and one was treated with carboplatin/gemcitabine. Overall, 3 out of the 1149 patients (0.3%) developed documented HBV reactivation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com