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In 1978 Sharp cofounded a pharmaceutical company called Biogen Ltd. (now Biogen Idec), which later developed agents to treat hairy-cell leukemia, non-Hodgkin lymphoma, and certain autoimmune disorders.
Today, all studies suggest that macrolides, and especially the more recently developed agents, are well tolerated.
Among 5-HT3 antagonists, ramosetron and palonosetron are recently developed agents.
Gemcitabine, paclitaxel, and some other newly developed agents have also been investigated in preclinical and clinical trials [ 3, 4, 12].
In addition, different regimens containing other recently developed agents could certainly be investigated in a similar manner.
Also, benefit from newly developed agents, for example, PARP inhibitors (Tutt et al, 2010), targeting DNA-repair-deficient cancers, might be expected.
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A growing number of researchers have developed agent-based models for simulating electricity markets.
We developed agent-based Monte Carlo models to simulate existing landmark HIV RCTs, such as the Partners in Prevention HSV/HIV Transmission Study.
Here, we propose a mathematical model using Gaussian function for the previously developed Agent Based Model (ABM) for Sensing of Emergent behavior in Complex Adaptive System (SECAS).
Thus, the aim of this study was the direct intra-individual in vivo comparison of different Aβ-targeted radiopharmaceuticals for PET imaging, including the newly developed agent [18F]FIBT.
FDA supplies similar guidance to drug developers (http://www.fda.gov/cder/guidance/index.htm), and guidance on developing agents to treat resistant pathogens is under development.
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