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Importantly, heterozygotes on 3-month HCHF diets developed accelerated lesions in the aortas and coronary arteries.
In this paper, the prediction of long-term strength of CFRP laminates for innovative marine use under water absorption conditions were performed by our developed accelerated testing methodology.
Sirt3− / − mice developed accelerated obesity, insulin resistance, and hyperlipidemia.
Indeed, only Bmal1 −/− mice developed accelerated aging phenotype, while other circadian mutants have near normal lifespan [ 11, 40].
In contrast, Stat4-deficient NZM (New Zealand mixed) mice developed accelerated nephritis and increased mortality in the absence of high levels of autoantibodies [ 25].
In the study of Moritani et al., NOD (Non-obese diabetic) mice expressing an IL-10 transgene in glucagon-producing pancreatic cells also developed accelerated diabetes [ 23].
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In this context, developing accelerated stress testing (AST) in order to assess quickly the long-term behavior of a semiconductor becomes extremely useful.
Due to the high cost of the development of new chemical entities and the current low overall productivity of obtaining successful candidates, the pharmaceutical industry is being required to develop accelerated POC strategies.
Although atherosclerosis occurs to a certain degree in all people, people with FH may develop accelerated atherosclerosis due to the excess level of LDL.
However, APP/CCR2−/− mice develop accelerated amyloid angiopathy and shortened lifespans.
Clinically, the presence of chronic inflammation is suggested by the persistent elevation in C-reactive protein and also in the propensity of individuals with T1D to develop accelerated atherosclerosis, which is now viewed as an inflammatory disorder, irrespective of glycemic control [13], [14].
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