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Hirudin is an inhibitor of thrombin and used as an effective anticoagulant, but has a potential to develop unacceptable immune responses.
To assess the effectiveness of infliximab (Remicade) in the treatment of patients with sarcoidosis who either do not respond to corticosteroids and other conventional drugs or develop unacceptable side effects to these drugs.
However, the disease eventually progress or patients develop unacceptable toxicities that limit these therapies.
Nonetheless, significant numbers of patients fail to respond or develop resistance to modern biological-based therapies or develop unacceptable side effects and severe infectious complications, long-term malignancies or secondary ADs.
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Winning all of these arguments is dependent on making the racism that has developed unacceptable.
Patients with SD or response were permitted to remain on study until they developed unacceptable toxicity or symptomatic disease progression.
In patients benefiting from combination therapy but developing unacceptable intolerance/toxicity to cetuximab or cisplatin/docetaxel, cisplatin/docetaxel or cetuximab may be continued as a single treatment and vice-versa.
12, 13 Treatment was continued until patients developed either unacceptable toxicity or disease progression.
This assessment model may help prevent costly project failures, system ambiguity late in development, unacceptable risks, cost overrun, and the inability to develop critical systems.
Given the proliferation of in-vehicle technologies, techniques must be developed to ensure devices do not produce unacceptable levels of distraction.
Shaheen asks: How do we best send the message that it's completely unacceptable to develop, much less use, these types of weapons?
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