By age 40, the brains of all people with Down syndrome develop the hallmark plaques and tangles of Alzheimer's and other signs of brain atrophy, autopsy studies have found.
These CF pigs also develop the hallmark phenotype of lung disease [ 23] and have led to a better understanding of the underlying causes of CF in humans.
Rogers et al. [ 39] have identified that the CFTR gene knockout model of pig better mimics human pathology than mouse models as they fail to develop the hallmark pancreatic, lung and intestinal obstructions that occur in humans.
However, Dresner-Pollak and coworkers indicated that reduced generation of osteoblasts has been found in bone marrow cell cultures obtained from IL-10 mice, and IL-10 mice develop the hallmarks of osteoporosis, that is, decreased bone mass, increased mechanical fragility, and suppressed bone formation [ 39].
Another, Greenpeace, developed the hallmark tactic of boarding vessels at sea to advertise its protests.
One large survey of Americans' mental health found that of those who said they had been exposed to trauma, about 25percentt developed the hallmarks of post-traumatic stress disorder.
In the female experiment analysed here, despite the fact that both AD/Lep and UN/Sal provoke the same thriftiness phenotypic switch within the liver, it is only the UN/Sal rats that subsequently develop the full hallmarks of metabolic syndrome when fed a high fat diet.
Many species of mammals, most notably primates, have been shown to develop the neuropathological hallmarks (both senile plaques and neurofibrillary tangles) of AD [ 7, 107] It has been hard for specialists to link changes in these animals' behavior to the underlying pathology because they are wild.
His eyes, which allow him to scan the court and see plays before they develop, are the hallmark of his game.
Moreover, failure of specific GABAergic neurons to develop is the hallmark of ablation of the C. elegans Ahr ortholog (Qin and Powell-Coffman 2004), as is the abnormal morphogenesis of legs, antennae, and bristles in Drosophila (Adachi-Yamada et al. 2005).
In retrospect, this seems odd, since I had developed the ultimate hallmark of depression, which is an obsession with suicide.
