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Although PSA is the primary biomarker for disease progression, patients may in some cases develop progression of disease due to development of (bone) metastases while PSA levels do not indicate such disease progression.
At least half of the patients diagnosed with non muscle-invasive bladder canon muscle-invasiveence recurrence and approximately 15% will develop progression to muscle invasive or metastatic disease.
One patient did not develop progression while on study and the PFS was censored at the date of his last visit.
The time to develop progression (PFS) was 32 weeks in the HDR-BRT group, 21 weeks in the resurgical group and 15 weeks in the chemotherapy alone group.
If the achievement of MCAM/MUC18 positivity is transitory, patients should not develop progression of melanoma disease; on the contrary, when persistent, patients could be at an increased risk of recurrence.
By excluding recurrent tumours with volume larger than 30 ml (n=76, 68%) and tumours that were subtotal resected (n=30, 27%) during treatment for the primary glioblastoma, the times to develop progression were extended in the re-resection and sole chemotherapy groups to 24 and 18 months, respectively but were not significantly different in the HDR-BRT.
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One patient developed progression due to brain metastasis.
However, all four patients with infection with a mixture of CMV gB genotypes developed progression to CMV disease (P=0.030).
He developed progression of the primary lesion.
When these two patients developed progression of disease, repeat biopsy of the melanoma showed ASS positive.
Among the remaining 11 patients, one developed progression after 3 cycles and 10 went on to receive CCRT.
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