The authors conclude "It may be that such persons are at higher risk of developing problematical use when they use these drugs" [ 20].
However, attempts at Rouen University to develop a system which would allow the formation of the PLBs on the horizontal axis showed that this approach was problematical.
Developing lepidopteran microsatellite DNA markers can be problematical, as markers often exhibit multiple banding patterns and high frequencies of non-amplifying "null" alleles.
And a buyout at Roosevelt Island, in the East River, would be especially problematical because of its unique jurisdiction: it is maintained, operated and developed by the Roosevelt Island Operating Corporation, which was created by the State Legislature.
Palladio further developed the basic plan of his Palazzo Iseppo Porto in the Palazzo Thiene (c. 1545 50), Vicenza, the largest and most problematical of his palace designs, of which only the side and rear blocks were completed.
Whether a failure to restore the normal net flow of resources to the developing countries would result in widespread defaults by the borrowers and insolvency for their commercial bank lenders, as the authors fear, is problematical.
Other ideas are more problematical.
"The Problematical Dr. Huang Hongyun," Jan 2005.
The timing is also problematical.
The last few yards are especially problematical.
