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The aim of the study was to develop probes to resolve these and other ambiguities.
Thus, there is an urgent need for efficient platforms to develop probes that can modulate protein function in cells to validate drug targets and to develop therapeutic leads.
We study how lipid probes based on pyrene-labeling could be designed to minimize perturbations in lipid bilayers, and how the same design principles could be exploited to develop probes which gauge lipid dynamics primarily within a single lipid monolayer or between them.
Recently, significant advances have been made to develop probes for targeting antigens commonly overexpressed in human cancer cells.
For long-term imaging and tracking of cells using Gd III -based contrast aGd III -basedecontrastto develop probes thagentsectitely label and are retaised by cells.
In keeping with this general theme, we review recent progress in using chemical approaches to develop probes that enable selective and direct detection of individual modifications within their native cellular environment.
Similar(52)
To carry out this search, the scientists developed probes that could latch onto genetic material from all known families of mammal viruses.
Their developed probes allowed the mapping of neurotransmitter release sites together with associated changes in cell topography that occur during exocytosis.
Moreover, this conformational transition was accompanied by spectral changes showing developed probes different pyrene excimer-monomer emission ratio triggered by pH changes.
Currently we are developing probes to assess other mitochondrial ROS, and it is also possible to design similar probes targeted to other cellular compartments.
Recently, Yoshiya et al. developed probes "LISA-4" and "LISA-101," which produce fluorescence as the result of an enzymatic reaction [ 23, 24].
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