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It stands to reason that the greater the number of hemorrhages, the greater likelihood the subject will develop pathology.
Additionally, Custer et al. have generated transgenic mice expressing VCP/p97 with the R155H and A232E mutations shown to develop pathology of the muscle, bone, and brain exhitibing similar characteristics seen in humans with IBMPFD [32].
Thus, α-syn knock-out mice did not develop pathology when preformed α-syn fibrils were injected.
In the absence of PrPC, PrPSc cannot be generated and PrP-null mice do not propagate infectivity or develop pathology on infection with PrPSc [ 28– 30].
The fact that cpdm/caspase-8+/– mice did not develop dermatitis, but do develop pathology in the other organs affected in cpdm mice, shows the importance of cell death of driving the skin inflammatory phenotype observed in the cpdm mice.
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The degree to which those neurons develop pathologies varies, both in terms of whether disease development has to be induced by external stressors and the severity of those pathologies.
Although many individuals experiencing stressful events do not develop pathologies, stress seems to be a provoking factor in those individuals with particular vulnerability, determined by genetic factors or earlier experience.
In captivity, they often develop pathologies, such as the dorsal fin collapse seen in 60 90% of captive males.
This is of primary importance as HIBM patients usually do not develop pathologies in other tissues than muscles.
Objectives of the study were to develop pathology-specific laboratory profiles and to increase the number of provisional diagnoses on laboratory test request forms.
The short-term objective of the project was to develop pathology-specific laboratory profiles, a new method for requesting laboratory tests that was based on strong scientific evidence of efficacy without reducing the physicians' power of discretion.
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