Sentence examples for develop new derivatives of from inspiring English sources

The inexorable rise of antibiotic resistance in clinically important bacteria makes it vital not only to identify new classes of antimicrobial compounds but also to develop new derivatives of existing compounds that can extend their effective use.

Herein, we provide an overview of CYP systems with particular emphasis on their role as drug targets, their involvement in drug biosynthesis and potential strategies for developing new derivatives of drugs based on CYP engineering.

Our findings provide a strong rationale for developing new derivatives of this lead compound that could be used in combination with cetuximab in cancer patients to improve clinical outcomes.

This means planning the development of a product family upon a platform, which allows shorter lead times in developing new derivative models.

To improve therapeutic efficacy against a broad range of human tumour cells, we must develop new and potent derivatives of rapamycin.

Following our studies of the melatoninergic receptors, we have developed new tetrahydronaphthalenic derivatives of melatonin that have been tested as selective melatonin receptors ligands.

In our continuous effort to develop new ligustrazine derivatives with neuroprotective effects, we attempted the synthesis of several ligustrazine-vanillic acid amide derivatives and screened their protective effect on the injured PC12 cells damaged by CoCl2.

This work further demonstrates the robustness of sulfoxide-containing MS-cleavable cross-linkers in XL-MS studies and provides a strong basis for us to further develop new DSSO derivatives and fully define protein protein interactions.

Mr. Hunter said he believes that the derivatives market will continue to grow and develop new kinds of contracts.

However, although these derivatives show a high structural similarity to coenzyme B12, their functionality might differ and offers the opportunity to develop new classes of antibiotic agents.

However novel antimicrobials (new derivatives of previously developed antimicrobials or newly developed antimicrobials) for effective monotherapy or at least inclusion in new dual antimicrobial therapy regimens (combined with previously developed antimicrobials or novel antimicrobials) will likely be required.