When challenged with doxorubicin (Adriamycin), these mice develop marked albuminuria, glomerulosclerosis, mitochondrial injury, and impaired autophagy of damaged mitochondria.
A. cyanophylla and E. camaldulensis had extensive rooting area and volume of fine roots, and both species tended to develop marked horizontal rooting, compared to C. glauca and C. siliqua.
In the absence of disease-modifying therapies, affected patients develop marked disability within some years after the onset of motor symptoms, which can be alleviated but eventually not prevented with currently available medical and surgical therapies.
In extreme cases, apoE4 mice also develop marked choroidal neovascularization, a hallmark of exudative AMD.
The testing of its Geostationary Launch Vehicle [GSLV], which cost £256 million to develop, marked a significant breakthrough in the race to send Indian astronauts into space and eventually make a lunar landing.
Of patients being treated by radiotherapy for cancer, a small proportion develop marked long-term radiation damage.
Amyloidosis is a surprisingly rare complication of CF, given the chronic inflammatory nature of the condition and the fact that all patients eventually develop marked bronchiectasis.
Mice co-expressing TDP-43WT and TDP-43Q331K mutant TDP-43 develop marked tremor at 3 weeks and rapidly progressive paralysis requiring euthanasia by 8 10 weeks.
64, 65 As the disease progresses, granulomatous lesions develop, marked by ingrowth of keratin pins on the erosion surface and progressive keratinization.
However, when placed on an HFD, FGF1 knockout mice develop marked fibrosis in adipose tissue, structurally restricting adipose tissue expansion and resulting in a severe diabetic phenotype.
