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Diabetic patients without clinical evidence of cardiovascular disease may develop left ventricular (LV) dysfunction.
This may predispose patients to develop left ventricular hypertrophy that is associated with an elevated high-sensitivity troponin level [ 7].
Children undergoing chronic hemodialysis are at risk of cardiovascular disease and often develop left ventricular hypertrophy (LVH).
These models develop left ventricular diastolic and systolic dysfunction comparable with the diabetic cardiomyopathy seen in patients [ 8].
HIV-negative individuals with the metabolic syndrome develop left ventricular systolic and diastolic load independent abnormalities indicating that MC adversely affects left ventricular function [ 21].
Since patients with type 2 diabetes are prone to develop left ventricular diastolic dysfunction, which often evolves over several years before symptoms occur [ 11], we hypothezised that E/Em could provide prognostic information also in this population.
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