Sentence examples for develop intolerance from inspiring English sources

If high dosages are being employed during the initial trial and during the initial period of therapy, many patients will develop intolerance and side effects and eventually shy away from the further use of indomethacin.

Overall, imatinib, dasatinib, and nilotinib are associated with manageable side effect profiles in most patients with CML; however, some patients have been found to develop intolerance to each of these TKIs 12– 12.

A relevant percentage of patients with metastatic renal cell carcinoma develop intolerance to vascular endothelial growth factor receptor-tyrosine kinase inhibitors (VEGFr-TKIs) and require careful selection of subsequent treatment.

Sunitinib has improved clinical outcomes for patients with progressive unresectable gastrointestinal stromal tumors (GIST) or who develop intolerance to imatinib mesylate and it is reasonably well tolerated [ 1- 5].

The contact lens acceptance was very high and only one patient developed intolerance to it.

A total of 11 patients (18%) developed intolerance to either the ventilation or the interface during NIV treatment.

Interestingly, these mice had impaired oral glucose tolerance from week 12, and later, at week 20, also developed intolerance to intravenous glucose loads.

Instead, Hamilton et al. [ 14] suggested that Cenozoic changes in sea level essentially stranded the ancestors of extant river dolphins in different river systems, where they subsequently developed intolerance to salt water on at least three occasions.

The aims of this study were to determine when patients develop feed intolerance, the prevalence of feed intolerance in subgroups, and other factors that influence feed intolerance.

Moreover, aberrant PASK expression and/or function may play a significant role in the development of diabetes and, interestingly, Pask−/− mice develop glucose intolerance on a high-fat diet [ 18].

The results showed a higher frequency of raised blood sugars in the feed-intolerant group both before and during feeding, with the time taken to develop feed intolerance being inversely proportional to the admission blood sugar level.