Sentence examples for develop insensitivity from inspiring English sources

A. aegypti was found to develop insensitivity within three hours of initial exposure, an effect correlated with a decline in olfactory receptor response to the chemical.

However, most tumour cells will eventually adopt as yet unclear mechanisms to develop insensitivity or resistance [6], [7].

However, majority of breast cancers develop insensitivity to conventional chemotherapy which provides only palliation and can induce systemic side effects.

While initially immensely effective in most patients, within 2 3 years, almost all patients with metastatic disease develop insensitivity to first-line androgen deprivation therapy (ADT) despite castrate levels of serum testosterone, a disease state now referred to as CRPC or, in the past, hormone-refractory or androgen-independent disease [ 15, 16].

Equine metabolic syndrome (EMS) is a recently described clinical disease in which horses develop insulin insensitivity similar to that described for T2DM in humans [103], [104], [105].

The emergence of secondary (acquired) resistance at some point during treatment soon became apparent when a clinical trial of imatinib in blast-crisis CML patients showed that some subjects had developed clinical insensitivity to the drug after remarkable but transient remission.

Data from transcriptomic profiling of patients [ 10] receiving ADT LHRHH agonists with anti-androgen flare protection [ 11]) for approximately 22 weeks were compared with our cell line model to determine what molecular changes were common to the two datasets, and to establish the suitability of our model system for studying drivers of developing androgen insensitivity in vivo.

He said he dealt with fame by developing "selective insensitivities".

The lipid abnormality is circulating diabetes and glucose intolerance (having tendency to develop the diabetes) patient by insensitivity of peripheral tissue of insulin [ 36].

Migration of barley to regions outside its place of origin was accelerated through mutations to develop reduced vernalization requirement and photoperiod insensitivity (Bothmer et al., 2003).

In ER+ve disease there is a lack of accepted biomarkers/signatures to distinguish endocrine-sensitive patients from those with intrinsic insensitivity or who will develop early or late resistance.