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For the methods, a four-step mixed methods approach newly constructed by the first author was used to define the scope of the research question and develop inclusion criteria.
Two of us (AM, DM) independently screened a representative sample of 250 articles, in order to develop inclusion and exclusion criteria.
Our findings contrast the initial report of Shortstop mice described by Slow et al. (9), which were reported to develop inclusion pathology without neurological consequences.
The YAC128 and BACHD mice express full-length htt (3144 amino acids, 67 exons) but ultimately develop inclusion pathology composed of small htt N-terminal fragments (26, 27).
Additionally, mice with an expanded polyQ knocked-in to their endogenous htt allele develop inclusion pathology containing smaller N-terminal fragments of mutant htt (19).
The conclusions in some studies are dependent on the quality of the data, and it is necessary to develop inclusion and exclusion criteria to evaluate a large body of data [ 29].
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In this sense, several transgenic models have been described that carry SNCA or LRRK2 mutations, and while many of these develop inclusions they fail to display robust neurodegeneration.
Firstly, definitions of ACO are not standardized, so we developed inclusion criteria that would allow us to identify patients with ACO from among a larger cohort of patients with COPD; our findings therefore cannot be generalized to populations identified using different criteria to define ACO.
Hall also developed Inclusion from WithIn (I WIn)® a low-cost, highly effective way for organizations to become more inclusive of all abilities and disabilities.
CX developed inclusion and exclusion criteria, contributed to the data analysis and interpretation of the data.
For the purpose of this study we have developed inclusion criteria for recruiting patients and for esophageal balloon insertion.
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